HIV Research Paper Example | Topics and Well Written Essays - 1000 words - 1

HIV - Research Paper Example HIV has not had a cure yet. However, antiretroviral drugs are use to slow down the immune system cells’ destruction. The discussion in this paper focuses on HIV phylogenetic classification and morphology, transmission and replication in the host, virulence and pathogeniciy factors, treatment, epidemiology and public control methods. Phylogenetic classification and morphology According to Fauci and Lane (n.d), HIV virion has a structure that is icosahedra. This virion contains external spikes. The spikes form from two main protein envelopes namely external gp120 and the transmembrane gp 41. On the surface of the infected cell, the viron buds form. These buds comprises of numerous host proteins. The main host proteins are Major Histocompartibility complex (MHC) class I and II antigens, which are incorporate into the host’s lipid bilayer. The strains classified as HIV-1 fall into three distinct groups. These categories are M or Major, Outlier or O and N or New or non M/non O. Group M nearly responsible for global pandemic. Group M forms properly defined clusters on phylogenetic trees. M group subtypes are labeled A-D, F-H, J-K. Other relevant clusters are circulating recombinant forms or CRFs. These recombination events form because of divergent HIV strains within host individuals. Transmission and replication For all persons infected with HIV, there is a variable degree of viruses in genital secretions and blood. This is the case regardless of whether or not the patient has visible symptoms. The transmission of HIV virus occurs when infected blood or secretions are exposed to tissues of the eye, vigina, anal area, and mouth, broken skin such as cuts or needle punctures. The most common transmission modes are sexual contact, needles sharing and infected mothers to newborns during labor pregnancy or breastfeeding. HIV is an RNA virus. The main process associated with HIV RNA is reverse transcription of genomic RNA to DNA. This process is facilitated b y enzyme reverse transcriptase. Replication cycle starts when gp 120 protein binds with high affinity. Once gp120 binds to CD4, it undergoes a conformational change that facilitates binding to one of the co-receptor groups. After the envelope, protein binds to CD4 molecule fusion occurs with the host cell membrane through the exposed gp41 molecule. The virus then penetrates plasma membrane of target cell then coiling upon to combine both the virion and immune system cells (Lama and Planelles, 2007). Virulence and pathogenicity factors HIV buds through the cell membrane. The virus is characterized by a capacity to cause disease. One attribute of HIV is replication and transmission, toxic, adherence and attachment and aggressiveness. For the virus, attachment to host immune system cell membrane is essential for virulence. This provides the opportunity to combine with the cells and cause reduction in protecting the body from diseases. In order to persist in the host, HIV virus has to r eplicate making it contagious. As a result, the virus is infectious. In order to survive, it has to remain aggressive. Aggressiveness comes with the ability to invade, multiply and survive in the tissues of the host. This makes HIV resistance to host defense mechanism. This virus also has high toxicity, which makes it possible to invade as many cells as possible. As a result, host immune

Reflective exercise for studing marketing module Essay

Reflective exercise for studing marketing module - Essay Example My knowledge on the topic of international marketing has improved tremendously as a result of the classes and lecture sessions. I have learnt that the strategies of marketing for internal businesses have become a crucial and cumbersome task in today’s competitive world. Globalisation is one of the most important contributing factors to international marketing strategies. My information was updated to a much greater extent in the areas of international marketing and its impact on global factors to an organization’s managerial decision making, the approaches of entering new markets, designing and developing new products for international markets, the attributes of marketing research internationally, the marketing mix for international business and a lot more. Our group comprised of three members including me. We had diverse cultural and ethnic backgrounds two of us are Chinese and one belonged to Saudi Arabia. Due to the difference in cultural and religious backgrounds I learnt how to communicate and manage a diverse team. We as a team found out that the business rules of International Marketing are not the same as they used to be few years ago. The reasons behind these change of rules and strategies is globalisation and its associated threats and opportunities. I got the information that due to various factors like increased globalisation, technological advancements and increased role of internet, the competition has increased greatly these days in every industry. Due to this reason, businesses have to adopt newer methods and strategies in order to survive in the competitive world and have a sustainable business. I also got familiar with the difference of conventional marketing and international marketing and due to this I realised that the modern marketers have changed their mind sets for global development. In today’s world the traditional ways of marketing are not sufficient for this reason the marketers and the executives need to be more innovative thinkers, create newer and better ideas to market internationally and possess quick decision making capabilities. The concept of innovation in marketing techniques was also highlighted in one of the lectures and I think this is one of the basic requirements for international marketing methods of today’s world. Examples of innovative marketing techniques are video clips posted on social networking websites and viral marketing. The conventional tools for assessing the decision making abilities of an organization which includes the SWOT analysis and the PESTL analysis are found to be quite different from a global business perspective. Important to note, that I studied and analysed that now more number of factors are needed to be analysed and examined in SWOT and PESTL analysis for a global organization. I would also like to accept and appreciate the skills of my teacher who encouraged and motivated us to learn the concepts of International marketing from a broader vi ew point and effectively implement it in the practical world when possible. The lectures, seminars and the reading materials were adequate enough to bring deeper insight in the students and held up to date information. We also studied and learnt to determine the opportunities present in the global marketing with the help of real-life case studies. Moreover, it was studied that the